BackgroundSkin-derived advanced glycation end products (sAGEs) have been associated with cardiovascular (CV) risk and mortality in adults.We hypothesize that cardiorespiratory fitness (CRF), body mass index (BMI) and vascular health are associated with development of sAGEs during childhood.MethodsIn our prospective cohort study, 1171 children aged
Around the world, the occurrence of landslides has become one of the greatest threats to human life, property, infrastructure, and natural environments.Despite extensive research and discussions on the spatiotemporal dependence of landslide displacements, there is still a lack of understanding concerning the factors that appear to control displacem
Bone marrow (BM)-derived endothelial progenitor cells (EPC) have therapeutic potentials in promoting tissue regeneration, but how these cells are modulated in vivo has been elusive.Here, we report that RBP-J, the critical transcription factor mediating Notch signaling, modulates EPC through CXCR4.In a mouse partial hepatectomy (PHx) model, RBP-J de